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Advanced filters: Author: Payal Damani-Yokota Clear advanced filters

Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation

Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lipolysis and catecholamine resistance, are lost during aging.

Elsie Gonzalez-Hurtado
Claire Leveau
Vishwa Deep Dixit
ResearchOpen Access02 Sept 2025
Nature Aging

Volume: 5, P: 1828-1843
Mouse genome rewriting and tailoring of three important disease loci

This study describes a method to insert large stretches of exogenous DNA into mammalian genomes, which is used to insert human ACE2 loci into mouse to produce a model of human SARS-CoV-2 infection.

Weimin Zhang
Ilona Golynker
Jef D. Boeke
ResearchOpen Access01 Nov 2023
Nature

Volume: 623, P: 423-431
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation

Mosquito-borne viruses are serious global public health threats associated with severe atypical cardiovascular manifestations. Here, the authors dissect how chikungunya virus directly infects cardiac tissue leading to heart disease and define key host pathways involved in viral cardiac persistence and tissue damage.

Maria G. Noval
Sophie N. Spector
Kenneth A. Stapleford
ResearchOpen Access03 Aug 2023
Nature Communications

Volume: 14, P: 1-17

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