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Showing 1–3 of 3 results
Advanced filters: Author: Peggy Janich Clear advanced filters

  • An analysis using ribosome-profiling and matched RNA-sequencing data for three organs across five mammalian species and a bird enables the comparison of translatomes and transcriptomes, revealing patterns of co-evolution of these two expression layers.

    • Zhong-Yi Wang
    • Evgeny Leushkin
    • Henrik Kaessmann
    Research
    Nature
    Volume: 588, P: 642-647

  • The circadian clock fine-tunes the activation state of epidermal stem cells by regulating their ability to respond to their microenvironment; perturbation of this clock affects long-term tissue homeostasis and predisposition to tumorigenesis.

    • Peggy Janich
    • Gloria Pascual
    • Salvador Aznar Benitah
    Research
    Nature
    Volume: 480, P: 209-214

  • A property of oncogene-induced senescence (OIS) is the induction of a secretory phenotype, termed the senescence-associated secretome (SASP). Gil and colleagues now provide evidence that senescence can be transmitted in a paracrine manner, by showing that induction of the SASP in cells undergoing OIS by inflammasome-mediated interleukin-1 signalling can promote senescence of normal neighbouring cells.

    • Juan Carlos Acosta
    • Ana Banito
    • Jesús Gil
    Research
    Nature Cell Biology
    Volume: 15, P: 978-990