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Showing 1–2 of 2 results
Advanced filters: Author: Pei-Xin Lim Clear advanced filters
  • Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. Here the authors reveal roles for the mouse SWS1–SWSAP1–SPIDR complex in inter-homolog recombination, including during meiosis, and sister chromatid exchange in BLM helicase deficient cells.

    • Rohit Prakash
    • Thomas Sandoval
    • Maria Jasin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
  • Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissue and a general reliance on BRCA2 in various tissues.

    • Elizabeth M. Kass
    • Pei Xin Lim
    • Maria Jasin
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10