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Advanced filters: Author: Peini Hou Clear advanced filters

  • Upon encounter of abasic lesions, a highly-prevalent DNA damage, RNA polymerase I experiences a two-step pausing-stalling mechanism that is described here through cryo-EM analysis. The structures uncover the nucleotide entry mechanism and provide insights into intrinsic RNA cleavage.

    • Alicia Santos-Aledo
    • Adrián Plaza-Pegueroles
    • Carlos Fernández-Tornero
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13