Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Nature (4)
Scientific Reports (1)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (5)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Cancer
Cell biology
Diseases
Immunology
Structural biology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–5 of 5 results

Advanced filters: Author: Pengbiao Xu Clear advanced filters

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

The ubiquitin proteasomal system degrades nuclear cGAS in cycling cells.

Pengbiao Xu
Ying Liu
Andrea Ablasser
ResearchOpen Access28 Feb 2024
Nature

Volume: 627, P: 873-879
The molecular basis of tight nuclear tethering and inactivation of cGAS

Structural studies show that cyclic GMP–AMP synthase binds to nucleosomes through its DNA-binding site, which maintains it in an inactive conformation and prevents self-DNA binding.

Baoyu Zhao
Pengbiao Xu
Pingwei Li
Research10 Sept 2020
Nature

Volume: 587, P: 673-677
Clathrin-associated AP-1 controls termination of STING signalling

The adaptor protein AP-1 controls the shutdown of STING signalling through a mechanism in which AP-1 recognizes a dileucine motif in phosphorylated STING, which leads to targeted transport of STING to the endolysosomal system for degradation.

Ying Liu
Pengbiao Xu
Andrea Ablasser
ResearchOpen Access19 Oct 2022
Nature

Volume: 610, P: 761-767
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

A molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 binding.

Baoyu Zhao
Fenglei Du
Pingwei Li
Research22 May 2019
Nature

Volume: 569, P: 718-722
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

Tiejun Li
Hao Cheng
Xiangshi Tan
ResearchOpen Access12 Jan 2016
Scientific Reports

Volume: 6, P: 1-14