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Showing 1–6 of 6 results
Advanced filters: Author: Penny L. Jeffery Clear advanced filters

  • Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

    • Roger L Milne
    • Karoline B Kuchenbaecker
    • Jacques Simard
    Research
    Nature Genetics
    Volume: 49, P: 1767-1778

  • Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.

    • Kyriaki Michailidou
    • Sara Lindström
    • Douglas F. Easton
    Research
    Nature
    Volume: 551, P: 92-94

  • Previous work has identified several genes where mutations lead to breast cancer, but other genetic and environmental factors must still be accounted for. A large study of genetic association with breast cancer points to four novel genes and many more genetic markers that should be pursued for their link to cancer susceptibility.

    • Douglas F. Easton
    • Karen A. Pooley
    • Bruce A. J. Ponder
    Research
    Nature
    Volume: 447, P: 1087-1093

    • Inge Seim
    • Penny L Jeffery
    • Lisa K Chopin
    Correspondence
    Nature Genetics
    Volume: 46, P: 525-526