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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

The (R)-enantiomer of 2-hydroxyglutarate, which is produced when IDH is mutated in human tumours, is shown to stimulate the activity of the EGLN prolyl 4-hydroxylases, leading to diminished levels of HIF and enhanced human astrocyte proliferation.

Peppi Koivunen
Sungwoo Lee
William G. Kaelin Jr
Research15 Feb 2012
Nature

Volume: 483, P: 484-488
A genetic mechanism for Tibetan high-altitude adaptation

Josef Prchal and colleagues identify a mutation in EGLN1 associated with adaptation to high altitude in Tibetan individuals. Their functional studies suggest a mechanism acting to reduce the erythropoietic response to hypoxia.

Felipe R Lorenzo
Chad Huff
Josef T Prchal
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 951-956
Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

Jenni Määttä
Niina Sissala
Peppi Koivunen
Amendments and CorrectionsOpen Access03 Mar 2020
Scientific Reports

Volume: 10, P: 1-3
Glutarate regulates T cell metabolism and anti-tumour immunity

Minogue et al. show that glutarate, a metabolite derived from tryptophan catabolism, has the ability to shape anti-tumour T cell responses by modulating pyruvate handling and alpha-ketoglutarate-dependent dioxygenases.

Eleanor Minogue
Pedro P. Cunha
Randall S. Johnson
ResearchOpen Access21 Aug 2023
Nature Metabolism

Volume: 5, P: 1747-1764
Iron drives anabolic metabolism through active histone demethylation and mTORC1

Shapiro, Chang, et al. identify a conserved role for the iron-binding histone demethylase KDM3B in sensing iron levels and regulating mTORC1 through transcriptional repression of key mTORC1 pathway components.

Jason S. Shapiro
Hsiang-Chun Chang
Hossein Ardehali
Research25 Sept 2023
Nature Cell Biology

Volume: 25, P: 1478-1494
Structural basis of homo- and heterotrimerization of collagen I

Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen I through specific intermolecular interactions.

Urvashi Sharma
Loïc Carrique
David J. S. Hulmes
ResearchOpen Access10 Mar 2017
Nature Communications

Volume: 8, P: 1-10
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

mTORC1 is an important regulator of muscle mass. Here, the authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner. PHD1 prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucine.

Gommaar D’Hulst
Inés Soro-Arnaiz
Katrien De Bock
ResearchOpen Access10 Jan 2020
Nature Communications

Volume: 11, P: 1-15
Hemoglobin levels are associated with retinal vascular caliber in a middle-aged birth cohort

Samuli Sakko
Mikko Karpale
Peppi Koivunen
ResearchOpen Access20 Apr 2024
Scientific Reports

Volume: 14, P: 1-9
Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up

Joona Tapio
Hannu Vähänikkilä
Peppi Koivunen
ResearchOpen Access07 Oct 2021
Scientific Reports

Volume: 11, P: 1-13
Higher hemoglobin levels are an independent risk factor for gestational diabetes

Niina Sissala
Sanna Mustaniemi
Peppi Koivunen
ResearchOpen Access31 Jan 2022
Scientific Reports

Volume: 12, P: 1-11
Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

Jenni Määttä
Niina Sissala
Peppi Koivunen
ResearchOpen Access11 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome)

Elisa Rahikkala
Matti Myllykoski
Johanna Uusimaa
ResearchOpen Access03 Apr 2019
Genetics in Medicine

Volume: 21, P: 2355-2363
Prognostic value of NT-proANP levels on major cardiovascular outcomes in a 31-year follow-up study depends on baseline morbidity

Samuli Sakko
Juha Perkiömäki
Joona Tapio
ResearchOpen Access28 May 2025
Scientific Reports

Volume: 15, P: 1-14
2-Oxoglutarate-dependent dioxygenases in cancer

This Review discusses the metabolic regulation of 2-oxoglutarate-dependent dioxygenases (2OGDDs) and how dysregulation of 2OGDDs in cancer, by genetic aberrations or environmental factors including hypoxia and/or the action of oncometabolites, can contribute to tumour development and growth.

Julie-Aurore Losman
Peppi Koivunen
William G. Kaelin Jr.
Reviews21 Oct 2020
Nature Reviews Cancer

Volume: 20, P: 710-726

Search

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

A genetic mechanism for Tibetan high-altitude adaptation

Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

Glutarate regulates T cell metabolism and anti-tumour immunity

Iron drives anabolic metabolism through active histone demethylation and mTORC1

Structural basis of homo- and heterotrimerization of collagen I

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Hemoglobin levels are associated with retinal vascular caliber in a middle-aged birth cohort

Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up

Higher hemoglobin levels are an independent risk factor for gestational diabetes

Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome)

Prognostic value of NT-proANP levels on major cardiovascular outcomes in a 31-year follow-up study depends on baseline morbidity

2-Oxoglutarate-dependent dioxygenases in cancer

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