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Showing 1–4 of 4 results
Advanced filters: Author: Percival Yang-Ting Chen Clear advanced filters

  • Marine natural products are often made by symbiotic microbes, but octocorals encode their own terpene cyclases that share features with bacterial versions and produce terpenoid precursors, including the coral-exclusive capnellane scaffold.

    • Immo Burkhardt
    • Tristan de Rond
    • Bradley S. Moore
    Research
    Nature Chemical Biology
    Volume: 18, P: 664-669

  • Biochemical and structural characterization of a standalone ketosynthase, SalC, reveals that it serves as a critical intramolecular aldolase and β-lactone synthase during biosynthesis of the core of the marine natural product salinosporamide A.

    • Katherine D. Bauman
    • Vikram V. Shende
    • Bradley S. Moore
    Research
    Nature Chemical Biology
    Volume: 18, P: 538-546

  • Crystal structures of a cobalamin-dependent radical S-adenosylmethionine (SAM) methylase reveal an unexpected mechanism that involves substrate-assisted catalysis whereby the carboxylate group of the co-substrate SAM serves as a general base.

    • Hayley L. Knox
    • Percival Yang-Ting Chen
    • Squire J. Booker
    Research
    Nature Chemical Biology
    Volume: 17, P: 485-491

  • Crystal structures are presented of Thermus thermophilus CarH, a photoreceptor that uses a vitamin B12 derivative, in all three relevant states: in the dark, both free and bound to operator DNA, and after light exposure.

    • Marco Jost
    • Jésus Fernández-Zapata
    • Catherine L. Drennan
    Research
    Nature
    Volume: 526, P: 536-541