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Showing 1–2 of 2 results
Advanced filters: Author: Perrine Courlet Clear advanced filters
  • On the basis of encouraging preclinical activity, an anti-CEACAM5 antibody–drug conjugate with a topoisomerase 1 inhibitor payload is being tested in an ongoing phase 1 trial where recommended doses for further testing have been identified and an unconfirmed overall response rate of 15% was observed in patients with metastatic colorectal cancer.

    • Scott Kopetz
    • Valentina Boni
    • Ildefonso Rodriguez-Rivera
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 3504-3513
  • Here the authors use drug susceptibility data from Plasmodium falciparum field isolates in a pharmacometric model to evaluate cabamiquine and pyronaridine efficacy, both individually and in combination. The combined treatment shows over 90% parasite reduction in most simulated cases, providing valuable guidance for clinical dose selection in real-world settings.

    • Mohamed Maiga
    • Laurent Dembele
    • Claudia Demarta-Gatsi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11