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Showing 1–3 of 3 results
Advanced filters: Author: Pete Crisalli Clear advanced filters

  • Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) is a proven methodology for in vitro RNA secondary structure analysis. The identification of a new acylating agent permits the use of SHAPE to probe folded RNAs within living cells.

    • Robert C Spitale
    • Pete Crisalli
    • Howard Y Chang
    Research
    Nature Chemical Biology
    Volume: 9, P: 18-20

  • The single-stranded nature of RNAs synthesized in the cell gives them great scope to form different structures, but current methods to measure RNA structure in vivo are limited; now, a new methodology allows researchers to examine all four nucleotides in mouse embryonic stem cells.

    • Robert C. Spitale
    • Ryan A. Flynn
    • Howard Y. Chang
    Research
    Nature
    Volume: 519, P: 486-490