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Showing 1–8 of 8 results
Advanced filters: Author: Peter Bieling Clear advanced filters

  • The assembly of branched actin networks depends on the heterodimeric capping protein CP/CapZ. Combining cryoEM, in vitro reconstitution and cell biological assays, the authors show that CP not only prevents actin filament elongation but also selectively masks actin filament ends to promote nucleation.

    • Johanna Funk
    • Felipe Merino
    • Peter Bieling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Release of inorganic phosphate (Pi) from actin marks older actin filaments for disassembly. Here, the authors show how Pi exits the F-actin interior through a ‘molecular backdoor’. The backdoor arrangement is distorted in a disease-linked actin variant.

    • Wout Oosterheert
    • Florian E. C. Blanc
    • Stefan Raunser
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1774-1785

  • Stabilization of a branch structure would intuitively suggest a direct connection between trunk and bough, but in actin filament networks, cortactin clamps the branching Arp2/3 complex to the daughter filament. This has fundamental consequences for mechanistic understanding of actin branch turnover and cortactin biology.

    • Klemens Rottner
    • Peter Bieling
    News & Views
    Nature Structural & Molecular Biology
    Volume: 31, P: 739-741

  • A combination of novel surface chemistry and fluorescence microscopy allows visualization of dynamic microtubules and plus-end tracking proteins in real time. Three microtubule binding proteins from fission yeast in the in vitro reconstitution system are used, and the results presented yield new insights into the mechanism of plus-end binding proteins in microtubule dynamics.

    • Peter Bieling
    • Liedewij Laan
    • Thomas Surrey
    Research
    Nature
    Volume: 450, P: 1100-1105

  • Entomopathogenic bacteria used for pest control secrete potent Tc toxins. Here, the authors combine biochemistry, solution and solid-state NMR spectroscopy and cryo-EM to show in atomic detail how the toxin disrupts the host cell cytoskeleton and kills the target cell.

    • Alexander Belyy
    • Florian Lindemann
    • Stefan Raunser
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12