Nature Search

De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

Steve Stegen
Shauni Loopmans
Geert Carmeliet
ResearchOpen Access15 Feb 2022
Bone Research

Volume: 10, P: 1-12
Integrin indecision

Antagonists of the α_vβ₃ and α_vβ₅ integrins inhibit angiogenesis in cancer, arthritis and ischemic retinopathy. However, a surprising new report suggests that knockout mice lacking β₃ and/or β₅ integrins show enhanced, rather than reduced angiogenesis. (pages 27–34)

Peter Carmeliet
News & Views01 Jan 2002
Nature Medicine

Volume: 8, P: 14-16
Growing better blood vessels

A polymer scaffold that delivers two angiogenic factors with distinct kinetics shows promise for engineering mature blood vessels.

Peter Carmeliet
Edward M. Conway
News & Views01 Nov 2001
Nature Biotechnology

Volume: 19, P: 1019-1020
VEGF inhibitors make blood

Findings in mice suggest that treatment with VEGF inhibitors prompts the upregulation of erythropoietin (Epo), a powerful cytokine and regulator of blood cell development. Could Epo be dulling the therapeutic effects of VEGF inhibition?

Christian Fischer
Peter Carmeliet
Edward M Conway
News & Views01 Jul 2006
Nature Medicine

Volume: 12, P: 732-734
Prioritization and functional validation of target genes from single-cell transcriptomics studies

Harnessing existing scRNA-seq data, a set of new tip endothelial cell markers is described to demonstrate the need for targeted assessment and prioritization of candidate genes.

Liliana Sokol
Anne Cuypers
Peter Carmeliet
ResearchOpen Access17 Jun 2023
Communications Biology

Volume: 6, P: 1-13
Blood vessels and nerves: common signals, pathways and diseases

Peter Carmeliet
Reviews01 Sept 2003
Nature Reviews Genetics

Volume: 4, P: 710-720
PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production

Jesús Gómez-Escudero
Cristina Clemente
Alicia G. Arroyo
ResearchOpen Access21 Oct 2019
Scientific Reports

Volume: 9, P: 1-18
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?

Anti-angiogenic drugs have become part of the standard therapeutics used to treat cancer. Despite this milestone, anti-angiogenic therapy still faces a number of clinical hurdles. Will other agents with complementary mechanisms offer novel opportunities for improved treatment?

Christian Fischer
Massimiliano Mazzone
Peter Carmeliet
Reviews01 Dec 2008
Nature Reviews Cancer

Volume: 8, P: 942-956
Adult Pgf^−/− mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor

Vanessa R. Kay
Lindsay S. Cahill
B. Anne Croy
ResearchOpen Access26 Jun 2019
Scientific Reports

Volume: 9, P: 1-14
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth

Caused by a compromised lymphatic system, lymphoedema leads to fluid retention and tissue swelling, and is treated primarily with physical therapy. Here the authors present a metabolic approach to reduce lymphoedema by providing the ketone body β-hydroxybutyrate or by feeding ketogenic diet, which increases lymphangiogenesis and reduces fluid retention in mice.

Melissa García-Caballero
Annalisa Zecchin
Peter Carmeliet
Research12 Jul 2019
Nature Metabolism

Volume: 1, P: 666-675
Author Correction: Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

Fei Wang
Peiwen Ding
Yonglun Luo
Amendments and CorrectionsOpen Access08 Nov 2022
Nature Communications

Volume: 13, P: 1-2
Gene prioritization through genomic data fusion

Stein Aerts
Diether Lambrechts
Yves Moreau
Research05 May 2006
Nature Biotechnology

Volume: 24, P: 537-544
RANKL regulates male reproductive function

There are few treatments for male infertility. Here, the authors show that the receptor activator of NF-κB ligand (RANKL) signalling pathway has important functions in sperm production and maturation, improves fertility in male mice and shows potential as a male infertility target.

Martin Blomberg Jensen
Christine Hjorth Andreassen
Anders Juul
ResearchOpen Access23 Apr 2021
Nature Communications

Volume: 12, P: 1-15
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Ong et al. report how YAP/TAZ and mTORC1 signalling intersect in endothelial cells to regulate nutrient acquisition and vascular growth.

Yu Ting Ong
Jorge Andrade
Michael Potente
ResearchOpen Access20 Jun 2022
Nature Metabolism

Volume: 4, P: 672-682
A genetic Xenopus laevis tadpole model to study lymphangiogenesis

Annelii Ny
Marta Koch
Peter Carmeliet
Research14 Aug 2005
Nature Medicine

Volume: 11, P: 998-1004
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential therapeutic strategy for this debilitating condition.

Jacqueline A. Maybin
Alison A. Murray
Hilary O. D. Critchley
ResearchOpen Access23 Jan 2018
Nature Communications

Volume: 9, P: 1-13
Weak neuronal glycolysis sustains cognition and organismal fitness

Jiménez-Blasco et al. show that neurons exhibit moderately low glycolytic rates despite their activity being mainly supported by glucose to preserve redox balance.

Daniel Jimenez-Blasco
Jesús Agulla
Juan P. Bolaños
ResearchOpen Access24 May 2024
Nature Metabolism

Volume: 6, P: 1253-1267
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Jack Leslie
Marina García Macia
Fiona Oakley
Amendments and Corrections10 Dec 2020
Nature Metabolism

Volume: 3, P: 118-119
Analyzing cell-type-specific dynamics of metabolism in kidney repair

Understanding dynamic metabolic changes in complex biological samples often overlooks heterogeneity in cell composition. Wang et al. combine mass spectrometry imaging, isotope tracing, and multiplexed immunofluorescence microscopy to study metabolic dynamics in the kidney upon ischemia–reperfusion.

Gangqi Wang
Bram Heijs
Ton J. Rabelink
ResearchOpen Access25 Aug 2022
Nature Metabolism

Volume: 4, P: 1109-1118
Impairment of 7F2 osteoblast function by simulated partial gravity in a Random Positioning Machine

Justin Braveboy-Wagner
Peter I. Lelkes
ResearchOpen Access07 Jun 2022
npj Microgravity

Volume: 8, P: 1-10
Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Andrei V Budanov
Tzipora Shoshani
Elena Feinstein
Research05 Sept 2002
Oncogene

Volume: 21, P: 6017-6031
Angiogenesis in health and disease

Peter Carmeliet
Reviews01 Jun 2003
Nature Medicine

Volume: 9, P: 653-660
Common mechanisms of nerve and blood vessel wiring

Peter Carmeliet
Marc Tessier-Lavigne
Reviews14 Jul 2005
Nature

Volume: 436, P: 193-200
Molecular mechanisms and clinical applications of angiogenesis

Peter Carmeliet
Rakesh K. Jain
Reviews18 May 2011
Nature

Volume: 473, P: 298-307
Single cell transcriptomics of human kidney organoid endothelium reveals vessel growth processes and arterial maturation upon transplantation

Marije Koning
Sébastien J. Dumas
Ton J. Rabelink
ResearchOpen Access01 Jul 2025
npj Regenerative Medicine

Volume: 10, P: 1-14
Mechanisms of angiogenesis and arteriogenesis

Peter Carmeliet
Reviews01 Apr 2000
Nature Medicine

Volume: 6, P: 389-395
Metabolism of stromal and immune cells in health and disease

This Review discusses stromal and immune cell metabolism and its implications for health and disease.

Bart Ghesquière
Brian W. Wong
Peter Carmeliet
Reviews09 Jul 2014
Nature

Volume: 511, P: 167-176
Angiogenesis in cancer and other diseases

Peter Carmeliet
Rakesh K. Jain
Reviews14 Sept 2000
Nature

Volume: 407, P: 249-257
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition

In this study, Morant-Ferrando, Jiménez-Blasco et al. show that fatty acid oxidation in astrocytes is necessary to maintain a specific configuration of the electron transport chain, which enables controlled production of reactive oxygen species that fine-tune neuron–glia metabolic coupling and support cognitive function.

Brenda Morant-Ferrando
Daniel Jimenez-Blasco
Juan P. Bolaños
ResearchOpen Access17 Jul 2023
Nature Metabolism

Volume: 5, P: 1290-1302
Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

This Review discusses the mechanisms that regulate stabilization of hypoxia-inducible factors (HIFs), and the pharmacological strategies to activate or inhibit HIFs in diseases such as ischaemia, inflammation, cancer, retinal neovascularization and pulmonary hypertension.

Xiaoyi Yuan
Wei Ruan
Holger K. Eltzschig
Reviews20 Dec 2023
Nature Reviews Drug Discovery

Volume: 23, P: 175-200
Phenotypic diversity and metabolic specialization of renal endothelial cells

The adult kidney vasculature comprises diverse populations of endothelial cells that support specific functions according to their microenvironment. This Review summarizes our current understanding of the phenotypic, molecular and metabolic heterogeneity of renal endothelial cells in relation to their microenvironment and the potential application of targeting renal endothelial cell metabolism as a therapeutic strategy for kidney diseases or kidney regeneration.

Sébastien J. Dumas
Elda Meta
Peter Carmeliet
Reviews25 Mar 2021
Nature Reviews Nephrology

Volume: 17, P: 441-464
The metabolic engine of endothelial cells

Falkenberg et al. summarise major metabolic pathways operating in endothelial cells, discuss their roles in the growth and function of blood and lymph vessels, and highlight therapeutic opportunities that arise from targeting endothelial cell metabolism.

Kim D. Falkenberg
Katerina Rohlenova
Peter Carmeliet
Reviews30 Sept 2019
Nature Metabolism

Volume: 1, P: 937-946
Glycolytic adaptation and progression of kidney disease

Studies of cellular energetics have revealed important roles of metabolic pathways in determining cell fate and response to injury. Insights from 2017 into the mechanisms underlying these pathways might identify therapeutic targets to minimize injury and promote repair.

Ton J. Rabelink
Peter Carmeliet
News & Views18 Dec 2017
Nature Reviews Nephrology

Volume: 14, P: 75-76
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy

Edward B. Brown
Robert B. Campbell
Rakesh K. Jain
Advertorial01 Jul 2001
Nature Medicine

Volume: 7, P: 864-868
Cerebrovascular disorders: molecular insights and therapeutic opportunities

Blood vessels in the CNS have traditionally been considered neutral bystanders that passively adapt in response to the needs of neural cells. This review surveys recent evidence that blood vessels actively participate in the pathogenesis of neurological disorders and the implications of this work for therapy.

Erik Storkebaum
Annelies Quaegebeur
Peter Carmeliet
Reviews26 Oct 2011
Nature Neuroscience

Volume: 14, P: 1390-1397
Phenotype molding of stromal cells in the lung tumor microenvironment

A comprehensive single-cell analysis of the lung cancer microenvironment reveals marked heterogeneity of transcriptional networks that defines novel clinically relevant stromal cell populations.

Diether Lambrechts
Els Wauters
Bernard Thienpont
Research09 Jul 2018
Nature Medicine

Volume: 24, P: 1277-1289
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

Charles C Wykoff
Christopher W Pugh
Peter J Ratcliffe
Research14 Dec 2000
Oncogene

Volume: 19, P: 6297-6305
A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

Benjamin Beck
Gregory Driessens
Cédric Blanpain
Research19 Oct 2011
Nature

Volume: 478, P: 399-403
FGF-dependent metabolic control of vascular development

Fibroblast growth factor receptor (FGFR) signalling is a crucial regulator of endothelial metabolism and vascular development.

Pengchun Yu
Kerstin Wilhelm
Michael Simons
Research03 May 2017
Nature

Volume: 545, P: 224-228
FOXO1 couples metabolic activity and growth state in the vascular endothelium

The transcription factor FOXO1 is identified as a crucial checkpoint of vascular growth, coupling the metabolic and proliferative activities of endothelial cells.

Kerstin Wilhelm
Katharina Happel
Michael Potente
Research06 Jan 2016
Nature

Volume: 529, P: 216-220
Ocular neovascularization: a valuable model system

Peter Anthony Campochiaro
Sean Francis Hackett
Reviews03 Oct 2003
Oncogene

Volume: 22, P: 6537-6548
Vasculogenesis in kidney organoids upon transplantation

Marije Koning
Sébastien J. Dumas
Ton J. Rabelink
ResearchOpen Access19 Aug 2022
npj Regenerative Medicine

Volume: 7, P: 1-16
A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma

J Lewin
K K Khamly
D M Thomas
ResearchOpen Access16 Oct 2014
British Journal of Cancer

Volume: 111, P: 2254-2261
Shaping the brain vasculature in development and disease in the single-cell era

The CNS critically relies on an extensive and complex vasculature to function properly. In this Review, Wälchli and colleagues examine the general and CNS-specific mechanisms that underlie angiogenesis in brain development, brain vascular malformations and brain tumours.

Thomas Wälchli
Jeroen Bisschop
Ivan Radovanovic
Reviews20 Mar 2023
Nature Reviews Neuroscience

Volume: 24, P: 271-298
Immunogenic cell death and DAMPs in cancer therapy

In recent years a new concept of immunogenic cell death (ICD) has emerged. In this Review, the authors discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and how this might relate to therapeutic intervention.

Dmitri V. Krysko
Abhishek D. Garg
Peter Vandenabeele
Reviews15 Nov 2012
Nature Reviews Cancer

Volume: 12, P: 860-875
Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth

Khalid Bajou
Catherine Maillard
Agnès Noel
Research02 Aug 2004
Oncogene

Volume: 23, P: 6986-6990
Oxygen-Induced Retinopathy in Mice: Amplification by Neonatal IGF-I Deficit and Attenuation by IGF-I Administration

Sophie Vanhaesebrouck
Hans Daniëls
Francis De Zegher
Research01 Mar 2009
Pediatric Research

Volume: 65, P: 307-310
O₂ regulates stem cells through Wnt/β-catenin signalling

Low oxygen levels are observed in the niche of some stem cells. The hypoxic transcription factor HIF-1 directly regulates Wnt signalling to ensure stem cells maintenance in these niches.

Jolly Mazumdar
W. Timothy O'Brien
M. Celeste Simon
Research19 Sept 2010
Nature Cell Biology

Volume: 12, P: 1007-1013
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Chunsik Lee
Rongyuan Chen
Xuri Li
ResearchOpen Access18 Aug 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds

Jie Li
Yan Zhou
De-hua Yang
Research16 Sept 2022
Acta Pharmacologica Sinica

Volume: 44, P: 680-692

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