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Showing 1–2 of 2 results
Advanced filters: Author: Peter Gochman Clear advanced filters

  • Transcriptome and functional studies in human iPSC-derived neurons suggest that the phenotypic effects of NRXN1 deletions can occur through reduction in wild-type NRXN1α isoform levels and expression of mutant NRXN1α isoforms.

    • Erin Flaherty
    • Shijia Zhu
    • Kristen J. Brennand
    Research
    Nature Genetics
    Volume: 51, P: 1679-1690

  • Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from patients with childhood-onset schizophrenia.

    • Gabriel E. Hoffman
    • Brigham J. Hartley
    • Kristen J. Brennand
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15