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Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo

Antibiotics and nutritional stresses can inactivate Pseudomonas aeruginosa efflux pump mexEFoprN. Here, the authors demonstrate that the inactivation of this efflux pump impacts quorum sensing mediated virulence in P. aeruginosa clinical isolates.

Sheryl E. Fernandes
Humberto Ortega
Peter Jorth
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-15
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors

Nerlov and colleagues show that expression of mKitL by cortical vascular endothelial cells is important for DN1 progenitor maintenance, whereas expression of mKitL by cortical thymic epithelial cells is required for maintaining DN2 progenitor cells.

Mario Buono
Raffaella Facchini
Claus Nerlov
Research18 Jan 2016
Nature Cell Biology

Volume: 18, P: 157-167
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

A plant mutant that fails to accumulate morphine provides a genetic clue to identifying the last two enzymes in this alkaloid biosynthetic pathway. Surprisingly, the proteins are non-heme dioxygenases, thus expanding the range of this versatile class of catalysts.

Jillian M Hagel
Peter J Facchini
Research14 Mar 2010
Nature Chemical Biology

Volume: 6, P: 273-275
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy

Characterization of four enzymes involved in biosynthesis of the plant metabolite and anticancer agent noscapine completes this pathway and identifies an unusual acetyl protecting group strategy that defines the order of enzymatic steps.

Thu-Thuy T Dang
Xue Chen
Peter J Facchini
Research08 Dec 2014
Nature Chemical Biology

Volume: 11, P: 104-106
Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation

Opium poppy accumulates alkaloids in the specialized cytoplasm of laticifers known as latex. Here the authors show that the binding of alkaloids to the abundant major latex proteins triggers quaternary structural modification that mediates a functional role for protein aggregation.

Natali Ozber
Samuel C. Carr
Peter J. Facchini
ResearchOpen Access09 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy

The opium poppy has been a source of painkilling drugs synthesized by the benzylisoquinoline alkaloid pathway. Here, the authors report an improved genome assembly and reveal gene clustering and copy number variation in alkaloid metabolic pathways.

Qiushi Li
Sukanya Ramasamy
Sam Yeaman
ResearchOpen Access04 Mar 2020
Nature Communications

Volume: 11, P: 1-13
Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae

Benzylisoquinoline alkaloids are a group of plant secondary metabolites with important pharmaceutical applications. Here, the authors have reconstituted a 10-gene alkaloid pathway in Saccharomyces cerevisiae, demonstrating the feasibility of producing commercially important alkaloids in microbial systems.

Elena Fossati
Andrew Ekins
Vincent J. J. Martin
Research11 Feb 2014
Nature Communications

Volume: 5, P: 1-11
Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

Neopinone isomerase catalyzes the isomerization of the opiate alkaloid neopinone to codeinone, driving the biosynthesis of codeine and morphine and preventing accumulation of their isomers neopine and neomorphine.

Mehran Dastmalchi
Xue Chen
Peter J. Facchini
Research18 Mar 2019
Nature Chemical Biology

Volume: 15, P: 384-390
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

A fusion protein containing P450 and aldo-keto reductase domains is shown to catalyze reticuline isomerization, the critical branch point between the noscapine and morphine biosynthetic pathways. This discovery completes the enzymatic route to morphine and related compounds.

Scott C Farrow
Jillian M Hagel
Peter J Facchini
Research01 Jul 2015
Nature Chemical Biology

Volume: 11, P: 728-732
A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

Although the conversion of (7S)-salutaridinol 7-O-acetate to thebaine can occur spontaneously, the identification of a thebaine synthase enzyme that catalyzes the reaction indicates how nature avoids the formation of labile hydroxylated byproducts.

Xue Chen
Jillian M. Hagel
Peter J. Facchini
Research28 May 2018
Nature Chemical Biology

Volume: 14, P: 738-743
Author Correction: Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy

Qiushi Li
Sukanya Ramasamy
Sam Yeaman
Amendments and CorrectionsOpen Access04 Jun 2020
Nature Communications

Volume: 11, P: 1
Suppression in transformed avian fibroblasts of a gene (CO6) encoding a membrane protein related to mammalian potassium channel regulatory subunits

Corinna Oberst
Ralf Weiskirchen
Klaus Bister
Research06 Mar 1997
Oncogene

Volume: 14, P: 1109-1116
Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms

Katherine Elliott
Daitoku Sakamuro
George C Prendergast
Research14 Jul 1999
Oncogene

Volume: 18, P: 3564-3573
Two ubiquitous aldo-keto reductases in the genus Papaver support a patchwork model for morphine pathway evolution

Conservation across the Papaver genus of two aldo-keto reductases catalyzing the second and penultimate steps in morphine biosynthesis reveals the latent activity of several enzymes and suggests a patchwork model of pathway evolution in opium poppy.

Samuel C. Carr
Fasih Rehman
Peter J. Facchini
ResearchOpen Access29 Oct 2024
Communications Biology

Volume: 7, P: 1-18
Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)

Ivette M. Menéndez-Perdomo
Peter J. Facchini
ResearchOpen Access20 Feb 2023
Scientific Reports

Volume: 13, P: 1-18
Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae

Jing Li
Eun-Jeong Lee
Peter J. Facchini
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-12

Search

Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

Acetylation serves as a protective group in noscapine biosynthesis in opium poppy

Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation

Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy

Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

Author Correction: Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy

Suppression in transformed avian fibroblasts of a gene (CO6) encoding a membrane protein related to mammalian potassium channel regulatory subunits

Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms

Two ubiquitous aldo-keto reductases in the genus Papaver support a patchwork model for morphine pathway evolution

Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)

Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae

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