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Showing 1–4 of 4 results
Advanced filters: Author: Peter Klavins Clear advanced filters

  • Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.

    • Julia S. Brunner
    • Loan Vulliard
    • Gernot Schabbauer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The folate pathway enzyme MTHFD1 is recruited to chromatin by BRD4. Inhibition of BRD4 or MTHFD1 similarly changes nuclear metabolite composition and gene expression, and dual inhibition synergistically impairs cancer cell viability.

    • Sara Sdelci
    • André F. Rendeiro
    • Stefan Kubicek
    Research
    Nature Genetics
    Volume: 51, P: 990-998

  • Topological superconducting systems are expected to exhibit a range of exotic physics which are particularly useful for application in quantum computing technologies. Here, the authors report the synthesis of LaNiGa2 which exhibits both topological and superconducting features originating from its nonsymmorphic crystal structure.

    • Jackson R. Badger
    • Yundi Quan
    • Valentin Taufour
    ResearchOpen Access
    Communications Physics
    Volume: 5, P: 1-8