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Showing 1–3 of 3 results
Advanced filters: Author: Peter Kunach Clear advanced filters

  • This study reveals near-atomic interfacial details of an Alzheimer’s Positron Emission Tomography (PET) molecule MK-6240 with its target disease marker, tau amyloid, showing MK-6240 mostly interacts with itself, like a pancake stack, which stabilizes an otherwise small interface with the amyloid.

    • Peter Kunach
    • Jaime Vaquer-Alicea
    • Sarah H. Shahmoradian
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-7

  • Aβ34 is generated from degradation of Aβ40 and Aβ42 by β-secretase. Here, the authors show that Aβ34 is a marker for amyloid clearance and is elevated in the CSF of patients that go on to convert from mild cognitive impairment to Alzheimer’s disease, suggesting it may be a useful biomarker.

    • Filip Liebsch
    • Luka Kulic
    • Gerhard Multhaup
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The authors used PET imaging to stage individuals according to the Braak neuropathological system for Alzheimer’s disease. PET stage was associated with biomarker and cognitive changes, highlighting the potential to stage Alzheimer’s disease in living people.

    • Joseph Therriault
    • Tharick A. Pascoal
    • Pedro Rosa-Neto
    ResearchOpen Access
    Nature Aging
    Volume: 2, P: 526-535