Nature Search

Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Sébastien Küry
Janelle E. Stanton
Elke Krüger
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Modulation of Anxiety-Like Behavior and Morphine Dependence in CREB-Deficient Mice

Olga Valverde
Theo Mantamadiotis
Rafael Maldonado
Research17 Mar 2004
Neuropsychopharmacology

Volume: 29, P: 1122-1133
Drug Addiction as a Pathology of Staged Neuroplasticity

Peter W Kalivas
Charles O'Brien
Reviews05 Sept 2007
Neuropsychopharmacology

Volume: 33, P: 166-180
Influence of ionic current on Na⁺ channel gating in crayfish giant axon

Peter Shrager
Mei-Ven C. Lo
Research01 Apr 1982
Nature

Volume: 296, P: 450-452
Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus

Oliver Leske
Christian Kaltschmidt
Hendrikje Werner
ResearchOpen Access05 Jul 2011
Nature Precedings

P: 1
Sex-specific transcriptional signatures in human depression

Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.

Benoit Labonté
Olivia Engmann
Eric J Nestler
Research21 Aug 2017
Nature Medicine

Volume: 23, P: 1102-1111
Feasibility of ApoC1 serum levels as tumor biomarker in glioblastoma patients: a pilot study

Michelle Hilbert
Peter Kuzman
Ulf Nestler
ResearchOpen Access10 Oct 2022
Scientific Reports

Volume: 12, P: 1-7
Evidence for cooperative interactions in potassium channel gating

Jan Tytgat
Peter Hess
Research01 Oct 1992
Nature

Volume: 359, P: 420-423
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex

Researchers identify a transcriptional network engaged in stress-resilient mice that is regulated by a previously unstudied transcription factor, Zfp189, and elucidate molecular mechanisms controlling this network and resilience behavior.

Zachary S. Lorsch
Peter J. Hamilton
Eric J. Nestler
Research19 Aug 2019
Nature Neuroscience

Volume: 22, P: 1413-1423
Correction: Corrigendum: Sex-specific transcriptional signatures in human depression

Benoit Labonté
Olivia Engmann
Eric J Nestler
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 525
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Siew et al. using multi-omic, physiological & imaging approaches have demonstrated that spaceflight causes kidney remodelling, suggesting a contribution to kidney stone formation, & that space radiation causes kidney damage & early signs of dysfunction.

Keith Siew
Kevin A. Nestler
Stephen B. Walsh
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-20
Mice with Chronically Elevated Dopamine Exhibit Enhanced Motivation, but not Learning, for a Food Reward

Barbara Cagniard
Peter D Balsam
Xiaoxi Zhuang
Research23 Nov 2005
Neuropsychopharmacology

Volume: 31, P: 1362-1370
Silent synapses dictate cocaine memory destabilization and reconsolidation

Cocaine-generated silent synapses dictate the encoding, consolidation, retrieval-induced destabilization and reconsolidation of cocaine memories, and these syapses can be targeted to reduce drug seeking and relapse.

William J. Wright
Nicholas M. Graziane
Yan Dong
Research02 Dec 2019
Nature Neuroscience

Volume: 23, P: 32-46
Impairments of Reversal Learning and Response Perseveration after Repeated, Intermittent Cocaine Administrations to Monkeys

J David Jentsch
Peter Olausson
Jane R Taylor
Research02 Aug 2001
Neuropsychopharmacology

Volume: 26, P: 183-190
Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine

While making up a small percentage of neurons in the nucleus accumbens, somatostatin interneurons may have important function in dopamine- and addiction-related behavior. Here, Ribeiro and colleagues show that somatostatin interneurons regulate behavioral responses to cocaine with physiological and transcriptomic changes.

Efrain A. Ribeiro
Marine Salery
Eric J. Nestler
ResearchOpen Access08 Aug 2018
Nature Communications

Volume: 9, P: 1-10
Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Stress resilience is accompanied by broad changes in gene expression. This study shows that estrogen receptor α (ERα) is a key upstream regulator of these changes in the nucleus accumbens, and that overexpression of ERα increases behavioral resilience via a sex-specific transcriptional mechanism.

Zachary S. Lorsch
Yong-Hwee Eddie Loh
Eric J. Nestler
ResearchOpen Access16 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress

Peter J Hamilton
Dominika J Burek
Elizabeth A Heller
Research02 May 2017
Neuropsychopharmacology

Volume: 43, P: 272-284
Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex

The Rett syndrome protein MeCP2 regulates gene transcription by binding to methylated DNA. Here the authors find that MeCP2 also regulates key neuronal genes by binding to nonmethylated DNA, providing new insights into the disorder.

Gyan Prakash Mishra
Eric X. Sun
Hume Stroud
Research22 Nov 2024
Nature Neuroscience

Volume: 28, P: 62-71
High-throughput cell and spheroid mechanics in virtual fluidic channels

High-throughput rheological measurements of cells and cell clusters by microfluidics is limited by fixed channel dimensions. Here the authors create virtual fluidic channels inside the cuvette of commercial flow cytometers to dynamically tune channel cross section to enable rheological measurements from cells and cell clusters.

Muzaffar H. Panhwar
Fabian Czerwinski
Oliver Otto
ResearchOpen Access04 May 2020
Nature Communications

Volume: 11, P: 1-13
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways.

Juan Pablo Lopez
Laura M. Fiori
Gustavo Turecki
ResearchOpen Access22 May 2017
Nature Communications

Volume: 8, P: 1-12
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain

Schahram Akbarian and colleagues report that mutation of the gene encoding the SETDB1 (KMT1E) histone methyltransferase in mouse neurons leads to dissolution of chromosome conformations and a topologically associated domain at the clustered protocadherin locus. They show that SETDB1 prevents excess CTCF binding and is important for maintaining developmentally important higher-order chromatin organization.

Yan Jiang
Yong-Hwee Eddie Loh
Schahram Akbarian
Research03 Jul 2017
Nature Genetics

Volume: 49, P: 1239-1250
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Polycystic Ovary Sydrome is a highly heritable, complex reproductive disorder with unknown underlying genetic factors. Here Hayes and Urbanek et al. identify three loci in European women strongly associated with neuroendocrine changes and disease susceptibility.

M. Geoffrey Hayes
Margrit Urbanek
Andrea Dunaif
ResearchOpen Access18 Aug 2015
Nature Communications

Volume: 6, P: 1-13
Correction: Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

M. Geoffrey Hayes
Margrit Urbanek
Andrea Dunaif
Amendments and CorrectionsOpen Access12 Feb 2016
Nature Communications

Volume: 7, P: 1
Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving

In rats self-administering cocaine, drug seeking behavior induced by a cocaine-paired cue increases progressively during cocaine withdrawal. The authors detected silent synapses in basolateral amygdala–to–nucleus accumbens projections during early withdrawal, but these synapses progressively disappeared during protracted withdrawal. Optogenetic 're-silencing' of these synapses decreased cue-induced cocaine seeking following withdrawal.

Brian R Lee
Yao-Ying Ma
Yan Dong
Research29 Sept 2013
Nature Neuroscience

Volume: 16, P: 1644-1651
Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection

Peter A Neumann
Yicun Wang
Yan Dong
Research14 Apr 2016
Neuropsychopharmacology

Volume: 41, P: 2399-2410
Lack of Effect of Chronic Antidepressant Treatment on Gs and Gi α-Subunit Protein and mRNA Levels in the Rat Cerebral Cortex

Masoumeh Emamghoreishi
Jerry J Warsh
Peter P Li
Research01 Sept 1996
Neuropsychopharmacology

Volume: 15, P: 281-287
Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder

Robert J Schloesser
Jian Huang
Husseini K Manji
Reviews03 Oct 2007
Neuropsychopharmacology

Volume: 33, P: 110-133
Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

M. Geoffrey Hayes
Margrit Urbanek
Andrea Dunaif
Amendments and CorrectionsOpen Access28 Apr 2020
Nature Communications

Volume: 11, P: 1
Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

It is widely assumed that D1 and D2 dopamine receptor-expressing striatal neurons code for discrete pathways in the basal ganglia. Combining optogenetics and electrophysiology, the authors show that this output architecture does not apply to nucleus accumbens neurons. Current thinking attributing D1/D2 selectivity to accumbens projections thus should be reconsidered.

Yonatan M Kupchik
Robyn M Brown
Peter W Kalivas
Research27 Jul 2015
Nature Neuroscience

Volume: 18, P: 1230-1232
Ambiguous-Cue Interpretation is Biased Under Stress- and Depression-Like States in Rats

Thomas Enkel
Donya Gholizadeh
Barbara Vollmayr
Research30 Dec 2009
Neuropsychopharmacology

Volume: 35, P: 1008-1015
Neuroplasticity: A New Window on Therapeutics in Neuropsychiatric Disease

Peter Kalivas
Husseini K Manji
Editorial28 Nov 2007
Neuropsychopharmacology

Volume: 33, P: 2
Regional Differences in Extracellular Dopamine and Serotonin Assessed by In Vivo Microdialysis in Mice Lacking Dopamine and/or Serotonin Transporters

Hao-wei Shen
Yoko Hagino
Ichiro Sora
Research30 Jun 2004
Neuropsychopharmacology

Volume: 29, P: 1790-1799
αCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior

Alanna C Easton
Walter Lucchesi
Christian P Müller
Research04 Mar 2013
Neuropsychopharmacology

Volume: 38, P: 1636-1647
Combined study of phase transitions in the P2-type Na_XNi_1/3Mn_2/3O₂ cathode material: experimental, ab-initio and multiphase-field results

Simon Daubner
Manuel Dillenz
Britta Nestler
ResearchOpen Access18 Apr 2024
npj Computational Materials

Volume: 10, P: 1-14
Striatal Dopaminergic and Serotonergic Markers in Human Heroin Users

Stephen J Kish
Kathryn S Kalasinsky
John W Haycock
Research01 May 2001
Neuropsychopharmacology

Volume: 24, P: 561-567
Perspective: The Manifest Destiny of Cocaine Research

Peter W Kalivas
Reviews04 Feb 2009
Neuropsychopharmacology

Volume: 34, P: 1089-1090
Non-invasive perturbations of intracellular flow reveal physical principles of cell organization

Mittasch et al. show that controlling cytoplasmic flow via focused-light-induced cytoplasmic streaming (FLUCS), a non-invasive technique, can be used to invert asymmetric cell division in Caenorhabditis elegans zygotes.

Matthäus Mittasch
Peter Gross
Moritz Kreysing
Research05 Feb 2018
Nature Cell Biology

Volume: 20, P: 344-351
Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum

Peter J. Hamilton
Emily Y. Chen
Eric J. Nestler
ResearchOpen Access22 Oct 2020
Scientific Reports

Volume: 10, P: 1-14
The Effects of NMDA Receptor Antagonists and Nitric Oxide Synthase Inhibitors on Opioid Tolerance and Withdrawal

Barbara H Herman
Frank Vocci
Peter Bridge
Reviews01 Dec 1995
Neuropsychopharmacology

Volume: 13, P: 269-293
Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding

Ina Buchholz
Thomas McDonnell
Mihaela Delcea
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
Reply: Clinical Implications of Cocaine-Induced Cortical Depression

Antonieta Lavin
Peter W Kalivas
Correspondence18 Apr 2005
Neuropsychopharmacology

Volume: 30, P: 1034-1035
Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals

Jianwen Liu
Joanne M Lewohl
R Dayne Mayfield
Research02 Nov 2005
Neuropsychopharmacology

Volume: 31, P: 1574-1582
Repeated Nicotine Exposure Enhances Reward-Related Learning in the Rat

Peter Olausson
J David Jentsch
Jane R Taylor
Research24 Jan 2003
Neuropsychopharmacology

Volume: 28, P: 1264-1271
Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model

Rebecca T Emeny
Jens Baumert
Karl-Heinz Ladwig
ResearchOpen Access25 May 2017
Neuropsychopharmacology

Volume: 43, P: 342-353
Narp Deletion Blocks Extinction of Morphine Place Preference Conditioning

Hans S Crombag
Mercy Dickson
Irving M Reti
Research04 Jun 2008
Neuropsychopharmacology

Volume: 34, P: 857-866
Context-specific Enhancement of Glutamate Transmission by Cocaine

Ken Bell
Patricia Duffy
Peter W Kalivas
Research01 Sept 2000
Neuropsychopharmacology

Volume: 23, P: 335-344
Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration

Tatyana Strekalova
Rainer Spanagel
Peter Gass
Research21 Jul 2004
Neuropsychopharmacology

Volume: 29, P: 2007-2017

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