Nucleotide excision repair protects the genome from UV light-induced damage. Here, Puumalainen et al. show that chromatin retention of the UV lesion sensors DDB2 and XPC due to a lack of p97 segregase impairs excision repair, revealing that DNA lesion-associated protein homeostasis affects genome stability.
- Marjo-Riitta Puumalainen
- Davor Lessel
- Hanspeter Naegeli
