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Showing 1–6 of 6 results
Advanced filters: Author: Peter R. Weigele Clear advanced filters

  • Using a CRISPR interference genetic approach, Bullen, Johnson, and colleagues discover a type IV restriction (TIV-RE) enzyme encoded on a mobilizable plasmid of multidrug resistant Enterococcus faecalis. This TIV-RE is a potent inhibitor of bacteriophage infection.

    • Nathan P. Bullen
    • Cydney N. Johnson
    • Breck A. Duerkop
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.

    • Geoffrey Hutinet
    • Witold Kot
    • Valérie de Crécy-Lagard
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • A few bacterial Cas9 nucleases have been repurposed as genome editing tools. Here, the authors use bioinformatic and biochemical analyses to characterize 79 Cas9 proteins, revealing substantial functional diversity and thus expanding the available toolbox of RNA-programmable CRISPR-associated nucleases.

    • Giedrius Gasiunas
    • Joshua K. Young
    • Virginijus Siksnys
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Two distinct Cas12a orthologs (Cme and Yme) from metagenomic sources are characterized. The enzymes are found to be thermotolerant and are compared to three mesophilic Cas12a enzymes (Lba, Fno and Asp).

    • Ryan T. Fuchs
    • Jennifer L. Curcuru
    • G. Brett Robb
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-16