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Showing 1–4 of 4 results
Advanced filters: Author: Peter Riger Clear advanced filters

  • KRAS is a proto-oncogene that is mutated in a wide variety of human cancers. Although this makes KRAS an obvious candidate for the development of targeted therapies, it has so far remained refractory to this approach. Systematic RNA interference is now used to detect synthetic lethal partners of oncogenic KRAS, revealing that TBK1 and NF-κB signalling are essential in KRAS mutant tumours. This may provide an alternative approach for targeting KRAS therapeutically.

    • David A. Barbie
    • Pablo Tamayo
    • William C. Hahn
    Research
    Nature
    Volume: 462, P: 108-112

  • A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and other related mosquito-borne flaviviruses, whereas hepatitis C virus is dependent on distinct entry factors, RNA binding proteins and FAD biosynthesis.

    • Caleb D. Marceau
    • Andreas S. Puschnik
    • Jan E. Carette
    Research
    Nature
    Volume: 535, P: 159-163

  • An in vivo RNA interference screening strategy in glioblastoma enabled the identification of a host of epigenetic targets required for glioblastoma cell survival that were not identified by parallel standard screening in cell culture, including the transcription pause–release factor JMJD6, and could be a powerful tool to uncover new therapeutic targets in cancer.

    • Tyler E. Miller
    • Brian B. Liau
    • Jeremy N. Rich
    Research
    Nature
    Volume: 547, P: 355-359