Nature Search

Author Correction: Next-generation information to support a sustainable course for European forests

Gert-Jan Nabuurs
Peter Verweij
Kees Hendriks
Amendments and Corrections30 Sept 2019
Nature Sustainability

Volume: 2, P: 1062
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

PdCO is a switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo, as demonstrated in a variety of contexts mainly in the mouse.

Jonas Wietek
Adrianna Nozownik
Ofer Yizhar
ResearchOpen Access29 May 2024
Nature Methods

Volume: 21, P: 1275-1287
Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors

Designing optogenetically functionalized G protein-coupled receptors (optoXRs) to mimic endogenous signaling in vivo is challenging. Here, the authors optimize the design of optoXRs by considering evolutionary conserved protein interactions, and they employ this approach in fruit flies.

Fangmin Zhou
Alexandra-Madelaine Tichy
Peter Soba
ResearchOpen Access19 Dec 2023
Nature Communications

Volume: 14, P: 1-18
Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

It is unclear how circuit specificity and function are maintained during organismal growth. In this study, authors show that connectivity between primary nociceptors and their downstream neurons scales with animal size and that Ste20-like kinase Tao acts as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity.

Federico Marcello Tenedini
Maria Sáez González
Peter Soba
ResearchOpen Access05 Aug 2019
Nature Communications

Volume: 10, P: 1-16
Neural circuits underlying context-dependent competition between defensive actions in Drosophila larvae

Neural circuit mechanisms underlying flexible defensive behaviors are not fully understood. Here authors show that mechanosensory information favors startle actions and activation of nociceptive pathways inhibits startle and promotes escape. Sensory context shapes the competitive selection between defensive actions by modulating the activity of escape promoting and startle inhibiting neurons.

Maxime Lehman
Chloé Barré
Tihana Jovanic
ResearchOpen Access28 Jan 2025
Nature Communications

Volume: 16, P: 1-21
BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons

Currently, bidirectional control of activity in the same neurons in the same experiment is difficult. Here the authors report a Bidirectional Pair of Opsins for Light-induced Excitation and Silencing, BiPOLES, which they use in a range of organisms including worms, fruit flies, mice and ferrets.

Johannes Vierock
Silvia Rodriguez-Rozada
J. Simon Wiegert
ResearchOpen Access26 Jul 2021
Nature Communications

Volume: 12, P: 1-20
Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior

Noxious thermal and mechanical stimuli have to be faithfully detected and avoided to ensure survival. In this study, the authors uncover a modality-specific circuit responsible specifically for mechanonociceptive behavior in Drosophila. They show that the escape response to mechanical but not thermal noxious stimuli requires multisensory integration by mechanosensory neurons and neuromodulatory feedback signaling.

Chun Hu
Meike Petersen
Peter Soba
Research12 Jun 2017
Nature Neuroscience

Volume: 20, P: 1085-1095
Next-generation information to support a sustainable course for European forests

Updated forest inventories are critical for policymaking. This study presents an approach to map coordinated top-down European forest management strategies that spatially weighs the multifunctionality of European forests. Such an approach should help identify pathways to manage forests sustainably.

Gert-Jan Nabuurs
Peter Verweij
Kees Hendriks
Research11 Sept 2019
Nature Sustainability

Volume: 2, P: 815-818
Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

The authors report that the presynaptic protein bassoon forms toxic aggregates in neuronal somata in multiple sclerosis. Stimulation of proteasomal activity reduces bassoon aggregates, neuroaxonal loss and disability during CNS inflammation.

Benjamin Schattling
Jan Broder Engler
Manuel A. Friese
Research22 Apr 2019
Nature Neuroscience

Volume: 22, P: 887-896
Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing

Aion is an anion-conducting, bistable channelrhodopsin that enables long-term silencing of neuronal networks, as demonstrated in organotypic hippocampal cultures and Drosophila melanogaster larvae.

Silvia Rodriguez-Rozada
Jonas Wietek
J. Simon Wiegert
ResearchOpen Access09 Jul 2022
Communications Biology

Volume: 5, P: 1-15
Author Correction: Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior

Jonas Wietek
Silvia Rodriguez-Rozada
J. Simon Wiegert
Amendments and CorrectionsOpen Access14 Mar 2018
Scientific Reports

Volume: 8, P: 1
Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior

Jonas Wietek
Silvia Rodriguez-Rozada
J. Simon Wiegert
ResearchOpen Access02 Nov 2017
Scientific Reports

Volume: 7, P: 1-18

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Author Correction: Next-generation information to support a sustainable course for European forests

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors

Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

Neural circuits underlying context-dependent competition between defensive actions in Drosophila larvae

BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons

Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior

Next-generation information to support a sustainable course for European forests

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing

Author Correction: Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior

Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior

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