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Stromal transcriptomics uncover LIF as a key effector in high tumor budding triple-negative breast cancer

Pimchanok Phankeaw
Suparada Khanaruksombat
Chanitra Thuwajit
ResearchOpen Access25 Nov 2025
Scientific Reports

Volume: 15, P: 1-18
Hippo pathway in cancer cells induces NCAM1⁺αSMA⁺ fibroblasts to modulate tumor microenvironment

Single-cell RNA sequencing reveals that the Hippo pathway in cancer cells influences the composition of cancer-associated fibroblasts and modulates the tumor microenvironment, thereby promoting cancer growth.

Chanida Thinyakul
Yasuhisa Sakamoto
Toshiro Moroishi
ResearchOpen Access17 Oct 2024
Communications Biology

Volume: 7, P: 1-15

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Stromal transcriptomics uncover LIF as a key effector in high tumor budding triple-negative breast cancer

Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment

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Hippo pathway in cancer cells induces NCAM1⁺αSMA⁺ fibroblasts to modulate tumor microenvironment