Influenza A virus must package eight separate genomic segments, called viral ribonucleoproteins (vRNPs). Using in situ cryo-electron tomography, the authors visualize how vRNPs are clustered on cell membranes containing the viral glycoprotein hemagglutinin or neuraminidase, and how the matrix protein M1 forms intracellular structures that reorganize during budding to support packaging.
- Moritz Wachsmuth-Melm
- Sarah Peterl
- Petr Chlanda
