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Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

CD98hc in macrophages attenuates the severity of colitis. This change in the macrophage development is associated with increased expression of apoptotic genes, suggesting that CD98hc maintains the gut homeostasis by ensuring the development of gut macrophages.

Philipp Wuggenig
Berna Kaya
Jan Hendrik Niess
ResearchOpen Access18 Mar 2020
Communications Biology

Volume: 3, P: 1-19
Microbial network disturbances in relapsing refractory Crohn’s disease

A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 323-336
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Amendments and Corrections07 Mar 2019
Nature Medicine

Volume: 25, P: 701
Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity

Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the colon improves glucose metabolism.

Theresa V. Rohm
Lena Keller
Claudia Cavelti-Weder
ResearchOpen Access19 Apr 2022
Communications Biology

Volume: 5, P: 1-15
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation

Mathias Schmaler
Alessia Colone
Gennaro De Libero
Research09 May 2018
Mucosal Immunology

Volume: 11, P: 1060-1070
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1

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Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

Microbial network disturbances in relapsing refractory Crohn’s disease

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity

Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation

Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

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