Reactivation of latent BK polyomavirus (BKV) infection is a major challenge in renal graft recipients and progression of BKV infection to BKV-associated nephropathy (BKVAN) leads to graft loss in up to 60% of affected patients. This Review discusses the available data on the diagnosis and monitoring of BKV infection and BKVAN, describes the known risk factors for BKV-related disease, and reviews current approaches to treatment and prevention of both BKV infection and BKVAN.
- Nina Babel
- Hans-Dieter Volk
- Petra Reinke
