A complex interplay of factors is thought to lead to adult-onset Still's disease, a rare systemic inflammatory disease. As discussed in this article, increased levels of several proinflammatory cytokines are thought to be important in the pathogenesis of this disease, and targeted treatments, such as biologic agents, are likely to increase in popularity.
- Petros Efthimiou
- Apostolos Kontzias
- Neeta S Ogden
