Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Peyton Greenside Clear advanced filters

  • Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.

    • Jeroen R. Huyghe
    • Stephanie A. Bien
    • Ulrike Peters
    Research
    Nature Genetics
    Volume: 51, P: 76-87

  • Off-target effects in CRISPR screens for essential regulatory elements have not been systematically evaluated. Here the authors find Cas9 nuclease, CRISPRi/a each have distinct off-target effects, and that these can be accurately identified and removed using the GuideScan sgRNA specificity score.

    • Josh Tycko
    • Michael Wainberg
    • Michael C. Bassik
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • A map of cohesin-mediated chromatin loops in 24 types of human cells identifies loops that show cell-type-specific variation, indicating that chromatin loops may help to specify cell-specific gene expression programs and functions.

    • Fabian Grubert
    • Rohith Srivas
    • Michael Snyder
    ResearchOpen Access
    Nature
    Volume: 583, P: 737-743

  • High-resolution contact maps of active enhancers and target genes generated by H3K27ac HiChIP in primary human cells provide rational guides to link noncoding disease-associated risk variants to candidate causal genes. Genes are validated by CRISPR activation and interference at connected enhancers and eQTL analysis, leading to a fourfold increase in the number of potential target genes for autoimmune and cardiovascular diseases.

    • Maxwell R Mumbach
    • Ansuman T Satpathy
    • Howard Y Chang
    Research
    Nature Genetics
    Volume: 49, P: 1602-1612

  • In vivo screening of pro-metastatic factors in a genetically engineered mouse model of lung cancer uncovered the CD109–JAK–STAT3 axis as a key contributor of metastatic dissemination of lung cancer cells. Activation of this pathway predicts poor outcome in patients with cancer, and its pharmacological inhibition dramatically reduces the metastatic ability of tumor cells, suggesting that it might be an effective intervention in patients.

    • Chen-Hua Chuang
    • Peyton G Greenside
    • Monte M Winslow
    Research
    Nature Medicine
    Volume: 23, P: 291-300

  • Howard Chang, Ravindra Majeti and colleagues define the chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types and in acute myeloid leukemia cells. They identify potential regulators governing hematopoietic differentiation and genetic elements linked to regulatory evolution in cancer cells.

    • M Ryan Corces
    • Jason D Buenrostro
    • Howard Y Chang
    Research
    Nature Genetics
    Volume: 48, P: 1193-1203