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Showing 1–6 of 6 results
Advanced filters: Author: Philemon S. Yang Clear advanced filters

  • Ca2+ channels and calmodulin (CaM) are two prominent hubs of biological signalling networks, affecting functions such as cardiac excitability and gene transcription. The prevailing view has been that the ultrastrong affinity of channels for the Ca2+-free form of calmodulin (apoCaM) ensures their saturation with CaM and yields a form of concentration independence between Ca2+ channels and CaM. Here, however, significant exceptions to this autonomy are shown to exist.

    • Xiaodong Liu
    • Philemon S. Yang
    • David T. Yue
    Research
    Nature
    Volume: 463, P: 968-972

  • Stromal cells play various roles in tumor establishment and metastasis. Here the authors, using an ex-vivo model, show that cancer-associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase-independent manner, likely by pulling and stretching the basement membrane to form gaps.

    • Alexandros Glentis
    • Philipp Oertle
    • Danijela Matic Vignjevic
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • A tethered ligand approach reveals that calcium-binding proteins (CaBPs) act as allosteric modulators of calcium channel calmodulin regulation, shedding light on how trace CaBPs can prevail over an abundance of CaM.

    • Philemon S Yang
    • Manu Ben Johny
    • David T Yue
    Research
    Nature Chemical Biology
    Volume: 10, P: 231-238

  • This protocol describes a nondestructive FRET-based assay for measuring protein interactions in cultured cells. The correlation between FRET efficiencies and relative protein concentration can be used to determine relative binding affinities.

    • Elisabeth S Butz
    • Manu Ben-Johny
    • Christian Wahl-Schott
    Protocols
    Nature Protocols
    Volume: 11, P: 2470-2498