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Showing 1–2 of 2 results
Advanced filters: Author: Philip E. Lapinski Clear advanced filters

  • Macropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to an endolysosomal compartment to sustain mTORC1 activation.

    • John C. Charpentier
    • Di Chen
    • Philip D. King
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Sudarshan Anand et al. show that endothelial cell expression of the microRNA miR-132 targets a negative regulator of Ras pathway signaling and thereby releases a brake to new blood vessel formation. miR-132 expression is upregulated in the endothelium of human hemangioma and tumor samples, and an antagonist of miR-132, delivered specifically to tumor endothelium using an integrin-targeted nanoparticle, was able to inhibit tumor angiogenesis and growth in mice.

    • Sudarshan Anand
    • Bharat K Majeti
    • David A Cheresh
    Research
    Nature Medicine
    Volume: 16, P: 909-914