Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. Here the authors show that the RNase III Drosha and DGCR8/Pasha, key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Their results suggest direct and miRNA-independent destabilization of proneural mRNAs by the microprocessor.
- Philip Knuckles
- Miriam A Vogt
- Verdon Taylor
