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Showing 1–2 of 2 results
Advanced filters: Author: Philip Maximilian Knaff Clear advanced filters

  • Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.

    • Lukas Wettstein
    • Tatjana Weil
    • Jan Münch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • This study describes the development and characterization of peptidomimetic inhibitors of TMPRSS2, which primes the Spike protein of SARS-CoV-2. The inhibitors are shown to prevent SARS-CoV-2 infection in cells as efficiently as camostat mesylate.

    • Lukas Wettstein
    • Philip Maximilian Knaff
    • Volker Mailänder
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-12