Priscilla Y. L. Tng et al. report a Cas13b-dependent way to suppress the transmissibility of RNA viruses chikungunya and dengue in mosquitoes. They use a virus-derived reporter and a CHIKV split replication system and demonstrate that Cas13b and gRNAs can inhibit virus-derived reporter RNAs in insect cells in vitro.
- Priscilla Ying Lei Tng
- Leonela Carabajal Paladino
- Luke Alphey
