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Showing 1–11 of 11 results
Advanced filters: Author: Philipp C. Nickels Clear advanced filters

  • Plasmonic resonances in nanoparticle helices arranged by the DNA origami method can give rise to strong circular dichroism at visible wavelengths. Schreiber et al. show that aligning and then toggling the orientation of such nanoparticle helices enables reversible switching of the dichroic response.

    • Robert Schreiber
    • Ngoc Luong
    • Tim Liedl
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-6

  • Lateral flow immunoassays (LFIAs) enable a rapid detection of analytes in a simple, paper-based test format, but their low sensitivity limits their applications. Here, the authors report a DNA origami-based signal amplification technology for LFIAs and apply it for the detection of cardiac troponin I in human serum.

    • Heini Ijäs
    • Julian Trommler
    • Maximilian J. Urban
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Retroviral integration of DNA into the host genome is a point of no return in the replication cycle but how efficient integration can take place remains unclear. Here the authors demonstrate that consecutive nucleoprotein intermediates are increasingly stable, resulting in a net forward rate.

    • Willem Vanderlinden
    • Tine Brouns
    • Jan Lipfert
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

    • Stig E Bojesen
    • Karen A Pooley
    • Alison M Dunning
    Research
    Nature Genetics
    Volume: 45, P: 371-384

  • Paul Pharoah, Joellen Schildkraut, Thomas Sellers and colleagues report a meta-analysis of genome-wide association studies for epithelial ovarian cancer and genotyping using the iCOGS array in 18,174 cases and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. They identify three new ovarian cancer susceptibility loci, including one specific to the serous subtype, and their integrated molecular analysis of genes and regulatory regions at these loci suggests disease mechanisms.

    • Paul D P Pharoah
    • Ya-Yu Tsai
    • Thomas A Sellers
    Research
    Nature Genetics
    Volume: 45, P: 362-370

  • HNF1B is overexpressed in the clear cell subtype and epigenetically silenced in the serous subtype of ovarian cancer. Pearce and colleagues now show that genetic variants in HNF1B are differentially associated with risks of developing these two cancer subtypes, possibly through an epigenetic mechanism.

    • Hui Shen
    • Brooke L. Fridley
    • Celeste Leigh Pearce
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • Self-assembled DNA nanostructures hold potential as nanomachines or platforms for organized chemical synthesis, but methods for assembly quality control are lacking. Here the authors use DNA-PAINT to quantify the incorporation and accessibility of individual strands in a DNA origami platform with molecular resolution.

    • Maximilian T. Strauss
    • Florian Schueder
    • Ralf Jungmann
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • Slow off-rate modified aptamer (SOMAmer) reagents are small and versatile probes for DNA-PAINT super-resolution microscopy that enable multiplexed, quantitative, and high-resolution imaging in fixed and live cells.

    • Sebastian Strauss
    • Philipp C. Nickels
    • Ralf Jungmann
    Research
    Nature Methods
    Volume: 15, P: 685-688