Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–19 of 19 results
Advanced filters: Author: Philipp Christen Clear advanced filters

  • Formate produced by synthetic methylotrophic E. coli can lead to carbon loss and negatively impact bioproduction efficiency. Here, the authors report the production of formate as a widespread property of NAD-dependent methanol dehydrogenases and identify Mdhs without this overoxidation activity.

    • Philipp Keller
    • Emese Hegedis
    • Julia A. Vorholt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Multi-template PCR enables parallel DNA amplification but suffers from sequence-specific biases. Here, the authors develop a 1D-CNN model predicting amplification efficiency directly from the DNA sequence and discover adapter-mediated self-priming as a key cause of uneven amplification during PCR.

    • Andreas L. Gimpel
    • Bowen Fan
    • Robert N. Grass
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Here, Santamaria de Souza et al. explore the context-dependent fitness effects of glpT-deficiency in Salmonella enterica, showing mutants thrive in the gut lumen but are counter-selected by macrophages, highlighting antagonistic pleiotropy and niche-dependent adaptation.

    • Noemi Santamaria de Souza
    • Yassine Cherrak
    • Wolf-Dietrich Hardt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Using one carbon compounds as feedstock is a promising approach in abating climate change. Here, the authors report the conversion of E. coli into a synthetic methylotroph that assimilates methanol via the ribulose monophosphate cycle and a set of distinctive mutations.

    • Philipp Keller
    • Michael A. Reiter
    • Julia A. Vorholt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.

    • Elena Mylonas
    • Kenichi Yoshida
    • Frederik Damm
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Protein chaperones help misfolded proteins reach their native state, but the necessarily unstable substrates have complicated the analysis of chaperone function. A stable misfolded luciferase substrate now allows the determination of traditional enzyme parameters for the DnaK system, demonstrating that five cycles of unfolding and release are needed for one successful refolding event.

    • Sandeep K Sharma
    • Paolo De Los Rios
    • Pierre Goloubinoff
    Research
    Nature Chemical Biology
    Volume: 6, P: 914-920

  • The engineering of methanol-dependent growth in Escherichia coli is challenging. Here, the authors predict and experimentally validate methanol-dependent strains with a complete RuMP cycle and high potential for the development of a methylotrophic platform organism.

    • Philipp Keller
    • Elad Noor
    • Julia A. Vorholt
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • The awareness of rock shape dependence in rockfall hazard assessment is growing, but experimental and field studies are scarce. This study presents a large data set of induced single block rockfall events quantifying the influence of rock shape and mass on its complex kinematic behaviour.

    • Andrin Caviezel
    • Adrian Ringenbach
    • Perry Bartelt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Engineering synthetic methylotrophy remains challenging. Here, the authors engineer a methanol-essential E. coli by an in silico-guided multiple knockout approach and show a laboratory evolved strain can incorporate up to 24% methanol into core metabolites during growth.

    • Fabian Meyer
    • Philipp Keller
    • Julia A. Vorholt
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Synthetic methylotrophic organisms provide potential for valorization of greenhouse gas-derived methanol. Here an Escherichia coli strain is generated that reaches a similar growth rate on methanol to many natural methylotrophs and is capable of producing chemicals from this carbon source.

    • Michael A. Reiter
    • Timothy Bradley
    • Julia A. Vorholt
    ResearchOpen Access
    Nature Catalysis
    Volume: 7, P: 560-573

  • Tradeoffs are central to life history theory and evolutionary biology, yet almost nothing is known about their mechanistic basis. Here the authors characterize one such mechanism and find a transposable element insertion is associated with the switch between alternative life history strategies.

    • Alyssa Woronik
    • Kalle Tunström
    • Christopher W. Wheat
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Large volumes of true random numbers are needed for increasing requirements of secure data encryption. Here the authors use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.

    • Linda C. Meiser
    • Julian Koch
    • Robert N. Grass
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • DNA has the capacity to store large amounts of information for very long durations. This protocol describes encoding of digital files as DNA and the error-free retrieval of the stored data from the sequenced data.

    • Linda C. Meiser
    • Philipp L. Antkowiak
    • Robert N. Grass
    Protocols
    Nature Protocols
    Volume: 15, P: 86-101