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Showing 1–7 of 7 results
Advanced filters: Author: Philipp Oberdoerffer Clear advanced filters

  • BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.

    • Jinping Liu
    • Alex Kruswick
    • Philipp Oberdoerffer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • DNA transactions promote torsional constraints that pose inherent risks to genome integrity. Here the authors identify the macro-histone splice variant macroH2A1.1 as an epigenetic modulator of topoisomerase 1-associated genome maintenance. MacroH2A1.1 expression determines sensitivity to TOP1 poisons and may present a cancer vulnerability.

    • Tae-Hee Lee
    • Colina X. Qiao
    • Philipp Oberdoerffer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Changes in chromatin structure are a conserved hallmark of ageing, and the mechanism driving these changes, as well as their functional significance, are heavily investigated. Loss of core histones is now observed in aged cells and may contribute to this phenomenon. Histone loss is coupled to cell division and seems to be triggered by telomeric DNA damage.

    • Philipp Oberdoerffer
    News & Views
    Nature Cell Biology
    Volume: 12, P: 1029-1031

  • Changes in nuclear architecture are a hallmark of ageing in yeast and mammals. These changes seem to be driven by DNA damage, which results in age-related alterations in gene expression, and may be a conserved cause of ageing.

    • Philipp Oberdoerffer
    • David A. Sinclair
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 692-702

  • Genome instability can lead to a number of human diseases, including neurodegeneration and cancer. In this Review, Zong et al. discuss the various ways in which RNA can both promote genome instability and contribute to genome maintenance.

    • Dali Zong
    • Philipp Oberdoerffer
    • André Nussenzweig
    Reviews
    Nature Reviews Genetics
    Volume: 21, P: 651-670