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Showing 1–18 of 18 results
Advanced filters: Author: Philipp R. Steen Clear advanced filters

  • The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off-the-shelf fluorescence microscopy hardware and reagents.

    • Susanne C. M. Reinhardt
    • Luciano A. Masullo
    • Ralf Jungmann
    ResearchOpen Access
    Nature
    Volume: 617, P: 711-716

  • Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour distances from experimental single-protein position data with those obtained from simulations based on a model of protein oligomerisation.

    • Luciano A. Masullo
    • Rafal Kowalewski
    • Ralf Jungmann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • The structure of a spontaneously activated immune protein is determined by cryo-electron microscopy. This reveals the passage of an entire domain through a transient opening. The authors investigate the mechanism by multiple biophysical approaches.

    • Trine Amalie Fogh Gadeberg
    • Martin Høgholm Jørgensen
    • Gregers Rom Andersen
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 884-895

  • In a post-approval study including more than 17,000 patients on the safety of pulsed field ablation, a new method for treatment of atrial fibrillation, the procedure was found to have a low rate of adverse events but was associated with some unexpected rare complications that will need further study.

    • Emmanuel Ekanem
    • Petr Neuzil
    • Vivek Y. Reddy
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 2020-2029

  • This study reports a dense, late summer phytoplankton bloom in the Southern Ocean that accumulated unusually high levels of organic matter and supported feeding hot spots for birds and whales. The authors show that this recurring open ocean bloom is driven by anomalies in easterly winds that push sea ice southwards and favour the upwelling of deep waters enriched in hydrothermal iron.

    • Sebastien Moreau
    • Tore Hattermann
    • Harald Steen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

    • Claudia L. Satizabal
    • Hieab H. H. Adams
    • M. Arfan Ikram
    Research
    Nature Genetics
    Volume: 51, P: 1624-1636

  • The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

    • Derrek P. Hibar
    • Hieab H. H. Adams
    • M. Arfan Ikram
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The antigen-B-cell-receptor interaction is the driving force of terminal B cell development that spans from B cell activation to antibody secreting plasma cells. Here authors determine, using DNA-PAINT super-resolution microscopy, how antigen affinity and valency define antigen binding to BCR in an in vitro system allowing precision control of these parameters.

    • Alexey Ferapontov
    • Marjan Omer
    • Søren Egedal Degn
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

    • Hieab H H Adams
    • Derrek P Hibar
    • Paul M Thompson
    Research
    Nature Neuroscience
    Volume: 19, P: 1569-1582

  • The dyes chosen for DNA-PAINT microscopy are pivotal for data quality. This Analysis shows a comprehensive comparison of 18 fluorescent dyes in DNA-PAINT and offers guidance for optimum dye selection in single-color and multiplexed imaging.

    • Philipp R. Steen
    • Eduard M. Unterauer
    • Ralf Jungmann
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1755-1762

  • Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

    • Edith Hofer
    • Gennady V. Roshchupkin
    • Sudha Seshadri
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

    • Barbara Franke
    • Jason L Stein
    • Patrick F Sullivan
    Research
    Nature Neuroscience
    Volume: 19, P: 420-431

  • Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

    • Derrek P. Hibar
    • Jason L. Stein
    • Sarah E. Medland
    Research
    Nature
    Volume: 520, P: 224-229