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Showing 1–4 of 4 results
Advanced filters: Author: Philipp Schnee Clear advanced filters

  • Winter warming in the Arctic will increase the CO2 flux from soils. A pan-Arctic analysis shows a current loss of 1,662 TgC per year over the winter, exceeding estimated carbon uptake in the growing season; projections suggest a 17% increase under RCP 4.5 and a 41% increase under RCP 8.5 by 2100.

    • Susan M. Natali
    • Jennifer D. Watts
    • Donatella Zona
    Research
    Nature Climate Change
    Volume: 9, P: 852-857

  • Based on a specificity analysis, ATRX and FANCM are discovered as substrates of NSD2. Moreover, an artificial NSD2 super-substrate is designed that is methylated very fast due to distinct hyperactive conformations of the NSD2-peptide complex.

    • Sara Weirich
    • Denis Kusevic
    • Albert Jeltsch
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-12

  • The SET-domain containing protein 2 (SETD2) is a protein lysine methyltransferase that has been shown to methylate the super-substrate peptide ssK36 100 times faster than the corresponding natural H3K36 peptide. Here, a combination of molecular dynamics simulations and biochemical experiments are applied to identify the mechanisms responsible for the increased activity of SETD2 towards ssK36.

    • Philipp Schnee
    • Michel Choudalakis
    • Albert Jeltsch
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-16