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Showing 1–10 of 10 results
Advanced filters: Author: Philippe Busso Clear advanced filters

  • Chromosome ends must be protected from fusion by NHEJ despite Ku binding to telomeres. Here, the authors show that at telomeres yeast Rap1 inhibits Ku’s translocation on DNA, preventing NHEJ and protecting telomeres without displacing Ku.

    • Stefano Mattarocci
    • Sonia Baconnais
    • Stéphane Marcand
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Different proteins localised at telomeres ensure chromosome end stability to prevent double strand-end break recognition. Here the authors provide new insight into how in S. cerevisiae the interaction between Rif2 and Rad50 inhibits MRX functions at telomeres.

    • Florian Roisné-Hamelin
    • Sabrina Pobiega
    • Stéphane Marcand
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Monitoring of western chimpanzee populations in Guinea-Bissau and Côte d’Ivoire reveals the presence of rare and different genotypes of Mycobacterium leprae, suggesting greater circulation in wild animals than previously thought.

    • Kimberley J. Hockings
    • Benjamin Mubemba
    • Fabian H. Leendertz
    ResearchOpen Access
    Nature
    Volume: 598, P: 652-656

  • Tuberculosis control is threatened by the continued emergence of drug-resistant strains. Here, Rybniker et al. screen a library of FDA-approved drugs and identify a gastric proton pump inhibitor that also has antituberculosis activity and targets the bacterial cytochrome bc1complex.

    • Jan Rybniker
    • Anthony Vocat
    • Stewart T. Cole
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Stewart Cole and colleagues report the genome sequence and comparative analyses of Brazilian, Indian, North American and Thai strains of Mycobacterium leprae, the etiologial agent of leprosy. They define 16 sub-types of M. leprae and examine their geographical distribution.

    • Marc Monot
    • Nadine Honoré
    • Stewart T Cole
    Research
    Nature Genetics
    Volume: 41, P: 1282-1289

  • Leprosy is caused by the yet-uncultured pathogen Mycobacterium leprae. Here, Benjak et al. obtain M. leprae genome sequences from DNA extracted from patients' skin biopsies and, by analysing 154 genomes from 25 countries, provide insight into the pathogen’s evolution and antimicrobial resistance.

    • Andrej Benjak
    • Charlotte Avanzi
    • Stewart T. Cole
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • In this Review, Aydin et al. discuss our current knowledge of the genomic, molecular and immunological make-up of penile squamous cell carcinoma and the findings of research studies to explore future therapeutic approaches in this disease.

    • Ahmet Murat Aydin
    • Jad Chahoud
    • Philippe E. Spiess
    Reviews
    Nature Reviews Urology
    Volume: 17, P: 555-570