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Showing 1–11 of 11 results
Advanced filters: Author: Philippe Hammann Clear advanced filters

  • This study shows that the tRNA-modifying enzymes TRM1A/TRM1B are essential to attain the steady-state pool of tRNAs and reveals how they functionally cooperate with RNase P in vivo for the early steps of tRNA biogenesis in Arabidopsis.

    • Mathilde Arrivé
    • Mathieu Bruggeman
    • Philippe Giegé
    Research
    Nature Plants
    Volume: 9, P: 2031-2041

  • This study characterized the unique protein subunit composition and structure of Arabidopsis mitochondrial ribosomes using biochemical assays and cryo-electron microscopy. Ten subunits are pentatricopeptide (PPR) proteins, among which rPPR1 functions as a translation factor.

    • Florent Waltz
    • Tan-Trung Nguyen
    • Philippe Giegé
    Research
    Nature Plants
    Volume: 5, P: 106-117

  • DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.

    • Thomas Dahlet
    • Matthias Truss
    • Michael Weber
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Circulating adiponectin controls sensitivity to insulin in tissues. Here, Arquier et al. show that adiponectin receptor activity in neurons of the Drosophila brain controls insulin response in peripheral tissues via juvenile hormone signaling.

    • Nathalie Arquier
    • Marianne Bjordal
    • Pierre Léopold
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Cytosolic RNA degradation by the RNA exosome requires the Ski complex. Here the authors show that the proteins RST1 and RIPR assist the RNA exosome and the Ski complex in RNA degradation, thereby preventing the production of secondary siRNAs from endogenous mRNAs.

    • Heike Lange
    • Simon Y. A. Ndecky
    • Dominique Gagliardi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAs

    • Hélène Scheer
    • Caroline de Almeida
    • Dominique Gagliardi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • VPS15 is known as a VPS34-associated protein that functions in intracellular trafficking and autophagy. Here the authors identify a role for VPS15 in ciliopathy and ciliary phenotypes, and show that it interacts with GM130 and functions in IFT20-dependent cis-Golgi to cilium trafficking.

    • Corinne Stoetzel
    • Séverine Bär
    • Hélène Dollfus
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Antimicrobial resistance is an increasing threat to public health and encouraging the development of new antimicrobials is one of the most important ways to address the problem. This Roadmap article aims to bring together industrial, academic and political partners, and proposes both short-term and long-term solutions to this challenge.

    • Marcus Miethke
    • Marco Pieroni
    • Rolf Müller
    Reviews
    Nature Reviews Chemistry
    Volume: 5, P: 726-749