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Showing 1–3 of 3 results
Advanced filters: Author: Phillip A. Dumesic Clear advanced filters

  • Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

    • Sumeet A. Khetarpal
    • Haobo Li
    • Anthony Rosenzweig
    Research
    Nature Cardiovascular Research
    Volume: 4, P: 1277-1294

  • Obesity and cancer-induced cachexia are linked to an impairment in the ability of muscle to use glucose or lipids interchangeably as energy substrates. Here, the authors propose that Drosophila REPTOR and its mammalian ortholog CREBRF act as key transcriptional regulators of fuel choice in muscle.

    • Pedro Saavedra
    • Phillip A. Dumesic
    • Norbert Perrimon
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Tissue nonspecific alkaline phosphatase (TNAP) within mitochondria hydrolyses phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation in thermogenic fat cells.

    • Yizhi Sun
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 593, P: 580-585