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Showing 1–8 of 8 results
Advanced filters: Author: Phillip A. Kohl Clear advanced filters

  • KdpFABC is a high-affinity bacterial K+ pump which combines the ion channel-like KdpA and the P-type ATPase KdpB. Here, the authors elucidate the mechanisms underlying transport and the coupling to ATP hydrolysis, and provide evidence that ions are transported via an intersubunit tunnel through KdpA and KdpB.

    • Jakob M. Silberberg
    • Robin A. Corey
    • Inga Hänelt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Spermine—a polyamine found in eukaryotic cells—mediates the assembly of taxol-stabilized microtubules into hexagonally packed bundles. It is now shown with electron microscopy and small-angle X-ray scattering that at higher concentrations of spermine the bundles disassemble and then reassemble into inverted tubulin tubules that expose the inner surface of the precursor microtubules, and that this results from spermine triggering a straight-to-curved conformation transition in the taxol-stabilized tubulin oligomers.

    • Miguel A. Ojeda-Lopez
    • Daniel J. Needleman
    • Cyrus R. Safinya
    Research
    Nature Materials
    Volume: 13, P: 195-203

  • This paper reports integrative molecular analyses of urothelial bladder carcinoma at the DNA, RNA, and protein levels performed as part of The Cancer Genome Atlas project; recurrent mutations were found in 32 genes, including those involved in cell-cycle regulation, chromatin regulation and kinase signalling pathways; chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far.

    • John N. Weinstein
    • Rehan Akbani
    • Greg Eley
    ResearchOpen Access
    Nature
    Volume: 507, P: 315-322

  • The Cancer Genome Atlas Network describe their multifaceted analyses of primary breast cancers, shedding light on breast cancer heterogeneity; although only three genes (TP53, PIK3CA and GATA3) are mutated at a frequency greater than 10% across all breast cancers, numerous subtype-associated and novel mutations were identified.

    • Daniel C. Koboldt
    • Robert S. Fulton
    • Jacqueline D. Palchik
    ResearchOpen Access
    Nature
    Volume: 490, P: 61-70

  • The Cancer Genome Atlas consortium reports on their genome-wide characterization of somatic alterations in colorectal cancer; in addition to revealing a remarkably consistent pattern of genomic alteration, with 24 genes being significantly mutated, the study identifies new targets for therapeutic intervention and suggests an important role for MYC-directed transcriptional activation and repression.

    • Donna M. Muzny
    • Matthew N. Bainbridge
    • Elizabeth Thomson.
    ResearchOpen Access
    Nature
    Volume: 487, P: 330-337