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Showing 1–5 of 5 results
Advanced filters: Author: Phillip Conklin Clear advanced filters

  • The role of nicotinic acetylcholine receptors in human cortical development remains largely unexplored. Here authors investigate CHRNA7 and CHRFAM7A, uncovering their involvement in radial glial cell proliferation and neuronal differentiation, and identify YAP1 as a downstream effector of cholinergic signaling.

    • Tanzila Mukhtar
    • Clara-Vita Siebert
    • Arnold R. Kriegstein
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Changes in gene regulation are a major driver of human traits and disease. Here, authors develop e2MPRA, a high-throughput technology that simultaneously measures enhancer activity and associated epigenetic modifications, revealing how sequence variants influence regulatory function.

    • Zicong Zhang
    • Ilias Georgakopoulos-Soares
    • Fumitaka Inoue
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-13

  • Grass ligules comprise the boundary between the leaf base and the photosynthetic blade; their homology has been debated for over 200 years. Cell-specific gene expression analyses suggest that ligules are homologous to the margins of the leaf base.

    • James W. Satterlee
    • Lukas J. Evans
    • Michael J. Scanlon
    ResearchOpen Access
    Nature Plants
    Volume: 9, P: 720-732

  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21