Misfolded α-synuclein in the gut contributes to Parkinsons’s disease pathogenesis and gut symptoms. Gut macrophages clear α-synuclein via C1q–complement pathways; loss of this response worsens neuropathology and improves gut function, implicating neuroimmune crosstalk.
- Phillip M. Mackie
- Joanne M. Koshy
- Habibeh Khoshbouei
