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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Binge eating disorder

Binge eating disorder is an eating disorder that is characterized by loss of control of eating behaviour and episodes of eating very large amounts of food. This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of binge eating disorder.

Katrin E. Giel
Cynthia M. Bulik
Stephan Zipfel
Reviews17 Mar 2022
Nature Reviews Disease Primers

Volume: 8, P: 1-19
A systematic review with meta-analyses of the relationship between recurrent binge eating and sleep parameters

Felipe Q. da Luz
Amanda Sainsbury
Renatha El Rafihi-Ferreira
Reviews29 Dec 2022
International Journal of Obesity

Volume: 47, P: 145-164

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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

A second update on mapping the human genetic architecture of COVID-19

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Binge eating disorder

A systematic review with meta-analyses of the relationship between recurrent binge eating and sleep parameters

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