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Showing 1–3 of 3 results
Advanced filters: Author: Phoebe S. Tsoi Clear advanced filters

  • The molecular mechanism between each progesterone receptor (PR) isoform and oncogenic co-regulators SRC3 and p300 is poorly understood. Here, the authors report PR isoform-specific interactions with these co-regulators and antagonist-driven protein interactions, challenging the classical model of nuclear receptor activation.

    • Matthew D. Mann
    • Min Wang
    • Patrick R. Griffin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.

    • Liya Hu
    • Banumathi Sankaran
    • B. V. Venkataram Prasad
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12