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Showing 1–2 of 2 results
Advanced filters: Author: Phung Gip Clear advanced filters

  • Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting a potential mechanism of immune surveillance escape.

    • Paola A. Betancur
    • Brian J. Abraham
    • Irving L. Weissman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Macrophage-mediated programmed cell removal (PrCR) allows clearance of living cells. Here the authors show that, in mouse models, activated macrophages create an “eat me” signal via calreticulin secretion on neutrophils during peritonitis and on cancer cells, determining in both cases clearance by PrCR.

    • Mingye Feng
    • Kristopher D. Marjon
    • Irving L. Weissman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15