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Advanced filters: Author: Pia Eixmann Clear advanced filters

  • Gene duplication often leads to paralogs with distinct functions. Here, the authors show that two paralogous proteins NRBP1 and NRBP2 oppositely regulate L1 retrotransposition by modulating L1 mRNA and ORF1p association, with NRBP2 promoting NRBP1 degradation via heterodimerization.

    • Wei Yang
    • Shaobo Cong
    • Wenjing Qi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20