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Showing 1–7 of 7 results

Advanced filters: Author: Pia Weikop Clear advanced filters

Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice

Early intervention during status epilepticus (SE) is important for long-term prognosis. Here, the authors show that pharmacological inhibition of adrenergic tone in the acute phase of SE enhances glymphatic clearance and improves short- and long-term outcomes.

Qian Sun
Sisi Peng
Fengfei Ding
ResearchOpen Access06 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Kjaerby and Andersen et al. show that norepinephrine (NE) plays profound roles in shaping sleep micro-architecture. NE slowly oscillates during sleep, with NE oscillatory amplitude being a major determinant of spindle-dependent memory consolidation and awakenings.

Celia Kjaerby
Mie Andersen
Maiken Nedergaard
Research07 Jul 2022
Nature Neuroscience

Volume: 25, P: 1059-1070
Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

Acute oedema after traumatic brain injury is accompanied by the suppression of glymphatic and lymphatic fluid flow due to excessive systemic release of noradrenaline.

Rashad Hussain
Jeffrey Tithof
Maiken Nedergaard
Research15 Nov 2023
Nature

Volume: 623, P: 992-1000
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for the allosteric site.

Per Plenge
Ara M. Abramyan
Claus J. Loland
ResearchOpen Access20 Mar 2020
Nature Communications

Volume: 11, P: 1-12
Effects of muscarinic M₁ receptor stimulation on reinforcing and neurochemical effects of cocaine in rats

Pia Weikop
Kathrine L. Jensen
Morgane Thomsen
Research28 Apr 2020
Neuropsychopharmacology

Volume: 45, P: 1994-2002
Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice

Simone Tonetto
Pia Weikop
Morgan Thomsen
ResearchOpen Access01 Mar 2024
Scientific Reports

Volume: 14, P: 1-16
Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

Christine Delle
Neža Cankar
Pia Weikop
ResearchOpen Access13 Mar 2023
Scientific Reports

Volume: 13, P: 1-11