Although two eukaryotic initiation factors (eIFs) are known to transmit signals to the small ribosomal subunit, it was unknown whether an eIF served a similar function for the large ribosomal subunit. This study shows that eIF6 communicates extracellular signals to the 60S subunit. Cells from an eIF6 heterozygous mouse show normal ribosome biogenesis but reduced translation, delayed cell cycle progression, and impaired transformation.
- Valentina Gandin
- Annarita Miluzio
- Stefano Biffo
