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Showing 1–5 of 5 results
Advanced filters: Author: Piergiuseppe Quarato Clear advanced filters

  • Experiments in mice show that designed epigenome editors that contain domains of transcriptional repressors can enable stable epigenetic silencing of Pcsk9, a gene with a role in cholesterol homeostasis, without inducing DNA breaks.

    • Martino Alfredo Cappelluti
    • Valeria Mollica Poeta
    • Angelo Lombardo
    ResearchOpen Access
    Nature
    Volume: 627, P: 416-423

  • During embryogenesis, the genome becomes transcriptionally active in a process known as zygotic genome activation (ZGA); how ZGA is initiated is still an open question. Here the authors show histone variant H2A.Z deposition precedes RNA polymerase II binding on chromatin, before ZGA. H2A.Z loss causes transcriptional downregulation of ZGA genes and leads to changes in the 3D genome organization.

    • Dafne Ibarra-Morales
    • Michael Rauer
    • Nicola Iovino
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • 22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.

    • Meetali Singh
    • Eric Cornes
    • Germano Cecere
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18